徐炜，男，1991年3月生，江苏泰州人，博士，威尼斯432888can食品科学与技术国家重点实验室、威尼斯432888can副研究员、硕士生导师。2014年本科毕业于合肥工业大学生物工程专业，2020年12月博士毕业于威尼斯432888can食品科学与工程专业。2019年9月-2020年9月在荷兰格罗宁根大学（University of Groningen）进行为期一年的国家公派博士联合培养，指导老师为Albert Guskov和Tjaard Pijning教授。主要研究方向包括L-阿拉伯糖异构酶、β-（2,6）果聚糖蔗糖酶等功能糖生物制造酶和L-天冬酰胺酶、真菌毒素降解酶及农兽药残降解酶等食品安全酶的定向挖掘、结构解析与功能强化。近五年，在Trends Food Sci. Technol., Cri. Rev. Food Sci., J. Agr. Food Chem., Carbohyd. Polym., Food Chem., Int. J. Biol. Macromol.等期刊发表相关SCI论文20余篇，其中IF>10论文共2篇。主持包括江苏省自然基金（青年基金）以及企业技术开发项目若干。
教育背景：
2017.09-2020.12，威尼斯432888can，食品科学与工程，博士
2019.09-2020.09，格罗宁根大学，生物大分子结构解析，博士联合培养
2014.09-2017.06，威尼斯432888can，食品科学与工程，硕士
2010.09-2014.06，合肥工业大学，生物工程，学士
研究方向：
食品酶工程、食品功能配料生物制造
1.十三五国家重点研发计划课题（2019YFC1604602），2019.01-2022.12，参与。
3.江苏省自然科学基金青年基金（BK20210463），2021.07-2023.06，主持。
3.企业横向项目，江苏奥迈生物科技有限公司，2021.12-2023.12，主持。
4.企业横向项目，江苏奥迈生物科技有限公司，2022.03-2024.03，主持。
代表性学术论文：
1. Xu. W, Ni, D., Hou, X., Pijning, T.*, Guskov, A., Rao, Y., Mu, W*. Crystal structure of levansucrase from the gram-negative bacterium Brenneria provides insights into its product size specificity. Journal of Agricultural and Food Chemistry, 2022, 70(16), 5095-5105.
2. Ni, D., Zhang, S., Huang, Z., Xu, W.*, Zhang, W., Mu, W. Directionally modulating the product chain length of an inulosucrase by semi-rational engineering for efficient production of 1-kestose. Enzyme and Microbial Technology, 2022, 110085.
3. Wang, Y., Wu, H., Zhang, W., Xu, W.*, Mu, W. Microbial production, molecular modification, and practical application of L-Asparaginase: A review. International Journal of Biological Macromolecules. 2021, 186, 975-983.
4. Wang, Y., Wu, H., Zhang, W., Xu, W.*, Mu, W. Efficient control of acrylamide in French fries by an extraordinarily active and thermo-stable L-asparaginase: A lab-scale study. Food Chemistry. 2021, 360, 130046.
5. Xu. W, Zhao, S., Zhang, W., Wu, H., Guang, C., Mu, W*. Recent advances and future prospective of organophosphorus-degrading enzymes: identification, modification, and application. Critical Reviews in Biotechnology, 2020, 41, 1091-1113.
6. Xu, W., Zhang, W., Zhang, T., Jiang, B., Mu, W*. L-Arabinose isomerases: Characteristics, modification, and application. Trends in Food Science and Technology, 2018, 78, 25-33.
7. Xu, W., Ni, D., Zhang W., Guang, C., Zhang, T., Mu, W*. Recent advances in levansucrase and inulosucrase: Evolution, characteristics, and application. Critical Reviews in Food Science and Nutrition, 2018, 22, 3630-3647.
8. Xu, W., Peng, J., Ni, D., Zhang W., Wu, H., Mu, W*. Preparation, characterization and application of levan/montmorillonite biocomposite and levan/BSA nanoparticle. Carbohydrate Polymers, 2020, 234, 115921.
9. Xu, W., Ni, D., Yu, S., Zhang, T., Mu, W*. Insights into hydrolysis versus transfructosylation: Mutagenesis studies of a novel levansucrase fromBrenneriasp. EniD312. International Journal of Biological Macromolecules. 2018, 116, 335-345.
10. Xu, W, Liu, Q, Bai, Y, Yu, S, Zhang, T, Jiang, B, Mu, W*. Physicochemical properties of a high molecular weight levan fromBrenneriasp. EniD312. International Journal of Biological Macromolecules, 2018, 109, 810-818.
11. Xu, W., Yu, S., Liu, Q., Zhang, T., Jiang, B., Mu, W*. Enzymatic production of melibiose from raffinose by the levansucrase fromLeuconostoc mesenteroidesB-512 FMC. Journal of Agricultural and Food Chemistry, 2017, 65: 3910-3918.
12. Xu, W., Zhang W, Zhang, T, Jiang B, Mu W*. L-Rhamnose isomerase and its use for biotechnological production of rare sugars. Applied Microbiology and Biotechnology, 2016, 100(7): 2985-29927.
13. Xu, W., Peng, J., Zhang W., Guang, C., Zhang, T., Mu, W*. Enhancement of theBrenneriasp. levansucrase thermostability by site-directed mutagenesis at Glu404 located at the “-TEAP-” residue motif. Journal of Biotechnology, 2019, 290, 1-9.
14. Xu, W., Lu, F., Wu, H., Zhang, W., Guang, C*. Identification of a highly thermostable mannitol 2-dehydrogenase fromCaldicellulosiruptor morganiiRt8.B8 and its application for the preparation of D-mannitol. Process Biochemistry, 2020, 96, 194-201.
15. Xu, W., Zhang, W., Tian, Y., Zhang, T., Jiang, B., Mu, W*. Characterization of a novel thermostable L-rhamnose isomerase fromThermobacillus compostiKWC 4 and its application for production of D-allose. Process Biochemistry, 2016, 53: 153-161.
16. Xu, W., Zhang W., Guang, C., Zhang, T., Mu, W*. A close look on the effect of polyethylene glycol on the levansucrase thermostability: a case study ofBrenneriasp. levansucrase. Journal of the Science of Food and Agriculture, 2019, 99, 6315-6322.
17. Xu, W., Liu, Q., Yu, S., Zhang, T., Mu, W*. Synthesis of lactosucrose using a recombinant levansucrase fromBrenneria goodwinii. Applied Biochemistry and Biotechnology. 2018, 1-14.
18. Xu, W., Fan, C., Zhang, T., Jiang, B., Mu, W*. Cloning, expression, and characterization of a novel L-arabinose isomerase from the psychrotolerant bacteriumPseudoalteromonas haloplanktis. Molecular Biotechnology, 2016, 58: 1-12.
19. Ni, D., Xu, W., T., Y., Zhang, W., Zhang, T., Guang, C., M., W*. Inulin and its enzymatic production by inulosucrase: Characteristics, structural features, molecular modifications and applications. Biotechnology Advances, 2019, 37(2): 306-318.
20. Tian, Y., Xu, W., Zhang, W., Zhang, T., Guang, C., Mu, W*. Amylosucrase as a transglucosylation tool: From molecular features to bioengineering applications. Biotechnology Advances, 2018, 36(5):1540-1552.
21. Zhang, Z., Chen, M., Xu, W., W Zhang, Zhang, T., Guang, C., M., W*. Microbial phospholipase D: Identification, modification and application. Trends in Food Science and Technology, 2020, 96, 145-156.
22. Tian, Y., Xu, W., Guang, C., Zhang, W., Mu, W*. Thermostable amylosucrase fromCalidithermus timidusDSM 17022: Insight into its characteristics and tetrameric conformation. Journal of Agricultural and Food Chemistry, 2019, 7(35): 9868-9876.
23. Ni, D., Zhu, Y., Xu, W., Pang, X., Lv, J., Mu, W*. Production and physicochemical properties of food-grade high-molecular-weightLactobacillusinulin. Journal of Agricultural and Food Chemistry, 2020, 68(21):5854-5862.
24. Zhang, Z., Xu, W., Wu, H., Zhang, W., M., W*. Identification of a potent enzyme for the detoxification of zearalenone. Journal of Agricultural and Food Chemistry, 2020, 68(1): 376-383.
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《酶工程原理与酶应用技术》
