王刚,威尼斯432888can教授、博士生导师,中国科学院生物物理研究所生物化学与分子生物学专业博士学位,英国Quadram Institute Bioscience访问学者。主要从事食品微生物学、食品营养与健康等方面的教学及研究工作。研究方向集中在肠道微生物与健康、功能性益生菌资源发掘、益生菌功能机制解析及益生菌产品开发。
近年来主持国家自然科学基金项目3项、军委科技委基础加强项目1项、江苏省“科技副总”项目1项,在权威期刊上发表第一作者研究论文16篇、通讯作者论文60余篇,h-index 32;获授权发明专利50余件(国际发明专利10件),并与拜耳(中国)、诺维信、无限极、上海光明等国际、国内知名企业开展了紧密的研发合作关系。与拜耳(中国)合作开发的产品在世博会上受到广泛关注,目前已服务超10万中国消费者。作为主要完成人获2014年中国商业联合会全国商业科技进步奖一等奖、2015年第十七届中国专利金奖和2018年教育部高等学校科学研究优秀成果奖科学技术进步奖二等奖。入选2022年度无锡市百名科技之星。
1.青春双歧杆菌基因型对宿主能量代谢的影响和生理作用:国家自然科学基金面上项目(32272332),主持,2023.01-2026.12
2.短双歧杆菌CCFM1025对小鼠肠脑轴中5-羟色氨酸及5-羟色胺合成转运的影响及其机制:国家自然科学基金面上项目(31972052),主持,2020.01-2023.12
3.植物乳杆菌对全氟化合物毒害的缓解及作用机制:)国家自然科学基金面上项目(31671839),主持,2017.01-2020.12
►代表性文章
1.Peijun Tian, Renyin Zou, Luyao Wang, Yin Chen, Xin Qian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang,Gang Wang*, Wei Chen. Multi-Probiotics Ameliorate Major Depressive Disorder and Accompanying Gastrointestinal Syndromes via Serotonergic System Regulation. Journal of Advanced Research, 2023, 45: 117-125
2.Peijun Tian, Ying Chen, Huiyue Zhu, Luyao Wang, Xin Qian, Renying Zou, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang,Gang Wang*, Wei Chen. Bifidobacterium breve CCFM1025 attenuates depression disorder via regulating gut microbiome and tryptophan metabolism: a randomized clinical trial. Brain Behavior and Immunity, 2022, 100:233-241
3.Qian Chen#, Shanshan Sun#, Chunxia Mei, Jianxin Zhao, Hao Zhang,Gang Wang*. Capabilities of bio-binding, antioxidant and intestinal environmental repair jointly determine the ability of lactic acid bacteria to mitigate perfluorooctane sulfonate toxicity. Environment International, 2022, 166, 107388
4.Lei Sun, Caixin Ni, Jianxin Zhao,Gang Wang*, Wei Chen. Probiotics, Bioactive Compounds and Dietary patterns for the Effective Management of Hyperuricaemia: A Review. Critical Reviews in Food Science and Nutrition, 2022, DOI: 10.1080/10408398.2022.2119934
5.Yufeng He, Liuting Shi, Yajin Qi, Qianqian Wang, Jianxin Zhao, Hao Zhang,Gang Wang*, Wei Chen. Butylated starch alleviates polycystic ovary syndrome by stimulating the secretion of peptide tyrosine-tyrosine and regulating faecal microbiota. Carbohydrate polymers, 2022, 287, 119304
6.Qian Chen, Qingmin Kong, Peijun Tian, Yufeng He, Jianxin Zhao, Hao Zhang,Gang Wang*, Wei Chen. Lactic acid bacteria alleviate di-(2-ethylhexyl) phthalate-induced liver and testis toxicity via their bio-binding capacity, antioxidant capacity and regulation of the gut microbiota. Environmental Pollution, 2022, 305,119197
7.Guangsu Zhu, Min Guo, Jianxin Zhao, Hao Zhang,Gang Wang*, Wei Chen. Bifidobacterium breve intervention combined with environmental enrichment alleviates cognitive impairment by regulating the gut microbiota and microbial metabolites in Alzheimer's disease mice. Frontiers in Immunology, 2022, 13:1013664
8.Peijun Tian†, Huiyue Zhu†, Xin Qian, Ying Chen, Zheng Wang, Jianxin Zhao, Hao Zhang,Gang Wang*, Wei Chen. Consumption of Butylated Starch Alleviates the Chronic Restraint Stress-Induced Neurobehavioral and Gut Barrier Deficits Through Reshaping the Gut Microbiota. Frontiers in Immunology, 2021, 12, 755481
9.Gang Wang, Ruili Pan, Xi Liang, Xiaobing Wu, Yanmin Wu*, Hao Zhang, Jianxin Zhao*, Wei Chen. Perfluorooctanoic acid-induced liver injury is potentially associated with gut microbiota dysbiosis. Chemosphere, 2021, 266, 129004
10.Peijun Tian, Kenneth J. O’Riordan, Yuan-kun Lee,Gang Wang*, Jianxin Zhao, Hao Zhang, John F. Cryan*, Wei Chen. Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice. Neurobiology of Stress, 2020, 12, 100216
11.Peijun Tian,Gang Wang*, Jianxin Zhao, Hao Zhang, Wei Chen*. Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis. Journal of Nutritional Biochemistry, 2019, 66:43-51
(1)2018年教育部高等学校科学研究优秀成果奖科学技术进步奖二等奖(第2完成人):生物减除食源性危害的益生菌开发与应用
(2)2015年第十七届中国专利金奖(第4完成人):一种具有排镉功能的植物乳杆菌及其用途
(3)2014年中国商业联合会科技进步奖一等奖(第2完成人):功能性益生乳酸菌的开发及产业化应用